Supply Yew bark extract Paclitaxel 98% CAS NO.33069-62-4

Paclitaxel is a monomer diterpenoid extracted from the bark of Natural Plant Taxus. It is a complex secondary metabolite. It is also the only drug known to promote microtubule polymerization and stabilize polymerized microtubules. Isotope tracing showed that paclitaxel only bound to polymerized microtubules and did not react with unpolymerized tubulin dimers. After contacting paclitaxel chemicalbook, cells will accumulate a large number of microtubules in cells. The accumulation of these microtubules interferes with various functions of cells, especially stops cell division in mitotic stage and blocks normal cell division. Paclitaxel is mainly used in ovarian cancer and breast cancer through the second - and third clinical study. It also has some effect on lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma and brain tumor.

Chemical Name: Paclitaxel
CAS No.: 33069-62-4

Chemical Structure: C47H51NO14

Molecular weight: 853.92

Appearance: White powder

Assay: 98%min

1.Antineoplastic drugs. It is used to treat metastatic breast cancer and metastatic ovarian cancer. Broad-spectrum antineoplastic botanical drugs are used to treat ovarian cancer, breast cancer and other diseases.

2.Broad-spectrum antineoplastic botanical drugs are used to treat ovarian cancer, breast cancer and other diseases.

3.Effective anti-tumor drugs; combination β- The N-terminal region of tubulin promotes highly stable microtubule formation, resists depolymerization, prevents normal cell division and capture in the G2 / M phase of the cell cycle.

4.The utility model relates to an anti microtubule drug, which can promote tubulin polymerization, inhibit depolymerization, maintain tubulin stability and inhibit cell mitosis. It acts on human endothelial cells with IC50 of 0.1 PM.