Supply Artichoke extract jolkinolide B 98% CAS NO.37905-08-1

With the increase of berberine B concentration, it can significantly inhibit the proliferation of MDA-MB-231 cells and block G1 cells. Compared with the blank group, 20-40 μ The mRNA expression of CyclinD1 and eIF4E was inhibited by mol-1 Euphorbia lactone B. the mRNA expression and protein level of cyclindchemicalbook1 in the transfected eIF4E siRNA group were also inhibited, and the cell cycle was blocked in G1 phase (P < 001, P < 0.01). Therefore, hallido B can inhibit the proliferation of human breast cancer cells and arrest the cell cycle in G1 phase. It may be due to its inhibition of eIF4E expression and the downregulation of CyclinD1 expression.

Chemical Name: jolkinolide B
CAS No.: 37905-08-1

Chemical Structure: C20H26O4

Molecular weight: 330.42

Appearance: White powder

Assay: 98%min

1. Jolkinolide B (JB) is the main component of Euphorbia chamaejasme. It was first published in Shennong herbal classic. Its root is used as medicine and toxic. It is used in the folk to treat skin, tuberculosis, tumor and other diseases. Diterpenoids separated from roots of Euphorbia Fischer root. Chemicalbook ester B from 17- hydroxyl rock Euphorbia Fischer can inhibit K562 cell growth and induce apoptosis in vitro, and find that it has a significant anti-inflammatory effect. In addition, studies have shown that it can induce apoptosis of MDA-MB-231 cells through inhibiting PI3K/Akt signaling pathway. It can be used in the treatment of malignant tumors.

1.Scientific research reagent，