Supply Angelica Root Extract Imperatorin 98% 482-44-0 CAS NO.482-44-0

The imperatorin extracted from the dried roots of the genus Umbelliferae has been shown to have antibacterial,
antiasthmatic,antiallergic, dilated blood vessels, and inhibition of tumor cell proliferation. Lipid microspheres and liposomes are drug carriers prepared by using natural lipid materials such as phospholipids and cholesterol. With this carrier, drugs can be transported to the site of the lesions, and the drug molecules can be protected from degradation by biological enzymes. The pre-prescription study and drug stability test of imperatorin can provide a theoretical basis for the design optimization of the injection of imperatorin microspheres. The application of lipid microsphere technology to the study of imperatorin drugs can reduce the renal side effects of drugs under the precursors that maintain efficacy.

Chemical Name: Imperatorin
CAS No.: 482-44-0

Chemical Structure: C16H14O4

Molecular weight: 270.28

Appearance: Light brown powder

Assay: 98%min

Effect on the central nervous system

The effect of imperatorin on seizures was studied using the maximal electroconvulsive epileptic seizure threshold model in mice.The study found that intraperitoneal injection of 50 and 100 mg/kg-1 of imperatorin 30 minutes earlier could increase the voltage threshold of seizures in mice by 38% and 68%, respectively, and demonstrated that imperatorin improves mice with electrical stimulation. The effect of the onset threshold is dose and time dependent.

Effects on the cardiovascular system

The chromatographic retention peaks of imperatorin and verapamil were similar. It can reduce the protein content and cell volume of cardiomyocytes prestimulated by angiotensin I, and its effect is dose-dependent: the ratio of heart weight of spontaneously hypertensive rats treated with angiotensin I is significantly reduced, indicating that the effect of angiotensin I on both in vivo and in vitro is anti-hypertrophy.

Antibacterial and antiviral activity

Imperatorin has significant antibacterial and antiviral activity. Seven components were extracted from the flowers of Magydaris tomcntosa, and four components, including eucrutin, were tested for bacteriostasis. It was found that eucrutin had strong inhibitory activity against both gram-positive and gram-negative bacteria (minimum bacteriostasis concentration was 32-128 mg-ml).

 

1.Common cold due to wind-cold pathogens manifested as headache, stuffy nose, etc;

2. Headache, toothache, especially pain in the forehead and superciliary region;

3. Various infections on the body surface. For the treatment of acute mastitis, it is often used with trichosanthes fruit, fritillary bulb and dandelion; for various kinds of sores and swellings, it is often used with honey suckle flower, trichosanthes fruit and other drugs;

4. Leukorrhagia. For patients with profuse clear and thin leukorrhea due to cold-dampness, this drug is often used with white atractylodes rhizome, poria and cuttlebone; for foul yellow thick leukorrhagia due to damp-heat, it is used with phellodendron bark, plantain seed and other drugs;

5. Stomachache. It can be used with liquorice, named Deoction of Dahurian Angelica and liquorice.

Analysis	Specification	Results
Assay	Imperatorin ≥98%	98.15%
Appearance	White powder	Complies
Ash	≤5.0%	1.5%
Moisture	≤5.0%	1.2%
Pesticides	Negative	Complies
Heavy metals	≤10ppm	Complies
Odor	Characteristic	Complies
Particle size	100%through 80 mesh	Complies
Microbioiogical:
Total of bacteria	≤1000cfu/g		Complies
Fungi	≤100cfu/g		Complies
Salmgosella	Negative		Complies
Coli	Negative		Complies
Storage     Store in cool & dry place. Do not freeze.                  Keep away from strong light and heat. Shelf life    2 years when properly stored